Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

MED1 (mediator subunit 1)co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. We observe significantly promoted onset, growth, metastasis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Yang, Yongguang, Leonard, Marissa, Luo, Zhenhua, Yeo, Syn, Bick, Gregory, Hao, Mingang, Cai, Chunmiao, Charif, Mahmoud, Wang, Jiang, Guan, Jun-Lin, Lower, Elyse E., Zhang, Xiaoting
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050805/
https://ncbi.nlm.nih.gov/pubmed/33691110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108822
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados