Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

Metabolic control is mediated by the dynamic assemblies and function of multiple redox enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates electrons and selectively activates numerous (>50 in humans and >300 in plants) cytochromes P450 (CYPs) controlling metaboli...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Jensen, Simon Bo, Thodberg, Sara, Parween, Shaheena, Moses, Matias E., Hansen, Cecilie C., Thomsen, Johannes, Sletfjerding, Magnus B., Knudsen, Camilla, Del Giudice, Rita, Lund, Philip M., Castaño, Patricia R., Bustamante, Yanet G., Velazquez, Maria Natalia Rojas, Jørgensen, Flemming Steen, Pandey, Amit V., Laursen, Tomas, Møller, Birger Lindberg, Hatzakis, Nikos S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050233/
https://ncbi.nlm.nih.gov/pubmed/33859207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22562-w
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