Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

Metabolic control is mediated by the dynamic assemblies and function of multiple redox enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates electrons and selectively activates numerous (>50 in humans and >300 in plants) cytochromes P450 (CYPs) controlling metaboli...

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Publicado no:Nat Commun
Main Authors: Jensen, Simon Bo, Thodberg, Sara, Parween, Shaheena, Moses, Matias E., Hansen, Cecilie C., Thomsen, Johannes, Sletfjerding, Magnus B., Knudsen, Camilla, Del Giudice, Rita, Lund, Philip M., Castaño, Patricia R., Bustamante, Yanet G., Velazquez, Maria Natalia Rojas, Jørgensen, Flemming Steen, Pandey, Amit V., Laursen, Tomas, Møller, Birger Lindberg, Hatzakis, Nikos S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050233/
https://ncbi.nlm.nih.gov/pubmed/33859207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22562-w
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