New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D(2) receptor regulation and signaling

The dopamine D(2) receptor (D(2)R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D(2)R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and interaction with arrestins. More recently, D(2)R arrestin-me...

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Udgivet i:Sci Rep
Main Authors: Mann, Anika, Keen, Alastair C., Mark, Hanka, Dasgupta, Pooja, Javitch, Jonathan A., Canals, Meritxell, Schulz, Stefan, Robert Lane, J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050214/
https://ncbi.nlm.nih.gov/pubmed/33859231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87417-2
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