Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the maintenance of human pluripotent stem cell (hPSC)...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Teo, Adrian Kee Keong, Nguyen, Linh, Gupta, Manoj K., Lau, Hwee Hui, Loo, Larry Sai Weng, Jackson, Nicholas, Lim, Chang Siang, Mallard, William, Gritsenko, Marina A., Rinn, John L., Smith, Richard D., Qian, Wei-Jun, Kulkarni, Rohit N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050001/
https://ncbi.nlm.nih.gov/pubmed/33667549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100495
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