Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the maintenance of human pluripotent stem cell (hPSC)...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Teo, Adrian Kee Keong, Nguyen, Linh, Gupta, Manoj K., Lau, Hwee Hui, Loo, Larry Sai Weng, Jackson, Nicholas, Lim, Chang Siang, Mallard, William, Gritsenko, Marina A., Rinn, John L., Smith, Richard D., Qian, Wei-Jun, Kulkarni, Rohit N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050001/
https://ncbi.nlm.nih.gov/pubmed/33667549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100495
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