Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation

Human embryonic stem cells are a type of pluripotent stem cells (hPSCs) that are used to investigate their differentiation into diverse mature cell types for molecular studies. The mechanisms underlying insulin receptor (IR)-mediated signaling in the maintenance of human pluripotent stem cell (hPSC)...

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Spremljeno u:
Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Teo, Adrian Kee Keong, Nguyen, Linh, Gupta, Manoj K., Lau, Hwee Hui, Loo, Larry Sai Weng, Jackson, Nicholas, Lim, Chang Siang, Mallard, William, Gritsenko, Marina A., Rinn, John L., Smith, Richard D., Qian, Wei-Jun, Kulkarni, Rohit N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050001/
https://ncbi.nlm.nih.gov/pubmed/33667549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100495
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