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Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Patients with an HNF1B(S148L/+) mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differentiated MODY5 human-induced pluripotent stem ce...

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Publicado en:Stem Cell Reports
Autores principales: Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788763/
https://ncbi.nlm.nih.gov/pubmed/26876668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.01.007
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