HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development of foregut-derived liver and pancreatic cells through differentiation of human i...

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發表在:iScience
Main Authors: Ng, Natasha Hui Jin, Jasmen, Joanita Binte, Lim, Chang Siang, Lau, Hwee Hui, Krishnan, Vidhya Gomathi, Kadiwala, Juned, Kulkarni, Rohit N., Ræder, Helge, Vallier, Ludovic, Hoon, Shawn, Teo, Adrian Kee Keong
格式: Artigo
語言:Inglês
出版: Elsevier 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562146/
https://ncbi.nlm.nih.gov/pubmed/31195238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.05.032
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