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Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a specific timespan in embryonic development through endothelial hematopoietic transition (EHT). We investigated th...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Blokzijl-Franke, Sasja, Ponsioen, Bas, Schulte-Merker, Stefan, Herbomel, Philippe, Kissa, Karima, Choorapoikayil, Suma, den Hertog, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049872/
https://ncbi.nlm.nih.gov/pubmed/33714985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01733-5
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