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Leveraging the cell lineage to predict cell-type specificity of regulatory variation from bulk genomics

Recent computational methods have enabled the inference of the cell-type-specificity of eQTLs based on bulk transcriptomes from highly heterogeneous tissues. However, these methods are limited in their scalability to highly heterogeneous tissues and limited in their broad applicability to any cell-t...

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Dettagli Bibliografici
Pubblicato in:Genetics
Autori principali: Yankovitz, Gal, Cohn, Ofir, Bacharach, Eran, Peshes-Yaloz, Naama, Steuerman, Yael, Iraqi, Fuad A, Gat-Viks, Irit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049554/
https://ncbi.nlm.nih.gov/pubmed/33734353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyab016
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