Neuromedin U uses Gα(i2) and Gα(o) to suppress glucose-stimulated Ca(2+) signaling and insulin secretion in pancreatic β cells

Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes, including impairment of pancreatic β-cell function via induction of mitochondrial dysfunction and endoplasmic reticulum (ER) stress, ultimately suppressing insulin secretion. NMU has...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Zhang, Weidong, Sakoda, Hideyuki, Nakazato, Yuki, Islam, Md Nurul, Pattou, François, Kerr-Conte, Julie, Nakazato, Masamitsu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049253/
https://ncbi.nlm.nih.gov/pubmed/33857254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250232
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg