Neuromedin U uses Gα(i2) and Gα(o) to suppress glucose-stimulated Ca(2+) signaling and insulin secretion in pancreatic β cells

Neuromedin U (NMU), a highly conserved peptide in mammals, is involved in a wide variety of physiological processes, including impairment of pancreatic β-cell function via induction of mitochondrial dysfunction and endoplasmic reticulum (ER) stress, ultimately suppressing insulin secretion. NMU has...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Weidong, Sakoda, Hideyuki, Nakazato, Yuki, Islam, Md Nurul, Pattou, François, Kerr-Conte, Julie, Nakazato, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049253/
https://ncbi.nlm.nih.gov/pubmed/33857254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250232
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