Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells

BACKGROUNDS AND AIMS: Activation of hepatic stellate cells (HSCs) is a central driver of fibrosis. This study aimed to elucidate the role of the deacetylase sirtuin 6 (Sirt6) in HSC activation and liver fibrosis. APPROACH AND RESULTS: Gain‐of‐function and loss‐of‐function models were used to study t...

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Veröffentlicht in:Hepatology
Hauptverfasser: Zhang, Jinhang, Li, Yanping, Liu, Qinhui, Huang, Ya, Li, Rui, Wu, Tong, Zhang, Zijing, Zhou, Jian, Huang, Hui, Tang, Qin, Huang, Cuiyuan, Zhao, Yingnan, Zhang, Guorong, Jiang, Wei, Mo, Li, Zhang, Jian, Xie, Wen, He, Jinhan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048913/
https://ncbi.nlm.nih.gov/pubmed/32535965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31418
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