SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (Sirt6), a nicotinamide adenine dinucleotide–de...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Zhong, Xiaolin, Huang, Menghao, Kim, Hyeong-Geug, Zhang, Yang, Chowdhury, Kushan, Cai, Wenjie, Saxena, Romil, Schwabe, Robert F., Liangpunsakul, Suthat, Dong, X. Charlie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327931/
https://ncbi.nlm.nih.gov/pubmed/32305562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.005
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