The impact of a 1‐hour time interval between pazopanib and subsequent intake of gastric acid suppressants on pazopanib exposure

Co‐treatment with gastric acid suppressants (GAS) in patients taking anticancer drugs that exhibit pH‐dependant absorption may lead to decreased drug exposure and may hamper drug efficacy. In our study, we investigated whether a 1‐hour time interval between subsequent intake of pazopanib and GAS cou...

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Dettagli Bibliografici
Pubblicato in:Int J Cancer
Autori principali: Krens, Stefanie D., Lubberman, Floor J. E., van Egmond, Marthe, Jansman, Frank G. A., Burger, David M., Hamberg, Paul, Vervenne, Walter L., Gelderblom, Hans, van der Graaf, Winette T. A., Desar, Ingrid M. E., van Herpen, Carla M. L., van Erp, Nielka P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2021
Soggetti:
Cancer Therapy and Prevention
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048885/
https://ncbi.nlm.nih.gov/pubmed/33428771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33469
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