The effect of gastrectomy on regorafenib exposure and progression‐free survival in patients with advanced gastrointestinal stromal tumours

AIMS: We investigated whether major gastrectomy influences the plasma exposure of regorafenib and treatment outcome. METHODS: Efficacy and pharmacokinetic data from 133 gastrointestinal stromal tumour patients included in a phase III trial were analysed. Patients were subdivided into 2 groups accord...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Lubberman, Floor J.E., van der Graaf, Winette T.A., Xu, Lei, Cleton, Adriaan, Demetri, George D., Gelderblom, Hans, van Erp, Nielka P.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783594/
https://ncbi.nlm.nih.gov/pubmed/31290566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14061
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