Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy

Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but the cascade mechanism in IVDD is not clear. We investigated the apoptosis of NPCs and IVDD when stimulated by norm...

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Vydáno v:Stem Cells
Hlavní autoři: Luo, Liwen, Jian, Xiuying, Sun, Hui, Qin, Jinghao, Wang, Yanqiu, Zhang, Ji, Shen, Zigang, Yang, Di, Li, Changqing, Zhao, Ping, Liu, MingHan, Tian, Zhiqiang, Zhou, Yue
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2021
Témata:
Tissue‐specific Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048856/
https://ncbi.nlm.nih.gov/pubmed/33459443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3322
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