Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy

Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but the cascade mechanism in IVDD is not clear. We investigated the apoptosis of NPCs and IVDD when stimulated by norm...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Luo, Liwen, Jian, Xiuying, Sun, Hui, Qin, Jinghao, Wang, Yanqiu, Zhang, Ji, Shen, Zigang, Yang, Di, Li, Changqing, Zhao, Ping, Liu, MingHan, Tian, Zhiqiang, Zhou, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2021
Assuntos:
Tissue‐specific Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048856/
https://ncbi.nlm.nih.gov/pubmed/33459443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3322
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