Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination

N‐Substituted α‐amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N‐substituted α‐amino esters through the direct reductive coupling of α‐ketoesters and amines employing sequence diverse metagenomic imine...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Yao, Peiyuan, Marshall, James R., Xu, Zefei, Lim, Jesmine, Charnock, Simon J., Zhu, Dunming, Turner, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048798/
https://ncbi.nlm.nih.gov/pubmed/33555620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016589
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