Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination

N‐Substituted α‐amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N‐substituted α‐amino esters through the direct reductive coupling of α‐ketoesters and amines employing sequence diverse metagenomic imine...

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Enregistré dans:
Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Yao, Peiyuan, Marshall, James R., Xu, Zefei, Lim, Jesmine, Charnock, Simon J., Zhu, Dunming, Turner, Nicholas J.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048798/
https://ncbi.nlm.nih.gov/pubmed/33555620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016589
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