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Abnormal synaptic pruning during adolescence underlying the development of psychotic disorders

PURPOSE OF REVIEW: Excessive synaptic pruning has first been suggested by Irwin Feinberg (1982) as an important pillar in the pathophysiology in schizophrenia (SCZ). This article reviews recent developments highlighting factors implicated in aberrant synaptic pruning and its contribution to disease...

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Detalhes bibliográficos
Publicado no:Curr Opin Psychiatry
Main Authors: Germann, Monique, Brederoo, Sanne G., Sommer, Iris E.C.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048735/
https://ncbi.nlm.nih.gov/pubmed/33560023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/YCO.0000000000000696
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