Cryo‐EM Resolves Molecular Recognition Of An Optojasp Photoswitch Bound To Actin Filaments In Both Switch States

Actin is essential for key processes in all eukaryotic cells. Cellpermeable optojasps provide spatiotemporal control of the actin cytoskeleton, confining toxicity and potentially rendering F‐actin druggable by photopharmacology. Here, we report cryo electron microscopy (cryo‐EM) structures of both i...

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發表在:Angew Chem Int Ed Engl
Main Authors: Pospich, Sabrina, Küllmer, Florian, Nasufović, Veselin, Funk, Johanna, Belyy, Alexander, Bieling, Peter, Arndt, Hans‐Dieter, Raunser, Stefan
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2021
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048601/
https://ncbi.nlm.nih.gov/pubmed/33449370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202013193
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