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Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability

During their life cycle, apicomplexan parasites, such as the malaria parasite Plasmodium falciparum, use actomyosin-driven gliding motility to move and invade host cells. For this process, actin filament length and stability are temporally and spatially controlled. In contrast to canonical actin, P....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pospich, Sabrina, Kumpula, Esa-Pekka, von der Ecken, Julian, Vahokoski, Juha, Kursula, Inari, Raunser, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635891/
https://ncbi.nlm.nih.gov/pubmed/28923924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707506114
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