Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer

In non‐small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase inhibitors. Despite impressive clinical responses, patients ultimately relapse as a reservoir of drug‐tolerant cells persist, which ultimately leads t...

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Foilsithe in:Int J Cancer
Main Authors: Giron, Philippe, Eggermont, Carolien, Noeparast, Amir, Vandenplas, Hugo, Teugels, Erik, Forsyth, Ramses, De Wever, Olivier, Aza‐Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons, Inc. 2021
Ábhair:
Molecular Cancer Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048518/
https://ncbi.nlm.nih.gov/pubmed/33210294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33404
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