Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer

In non‐small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase inhibitors. Despite impressive clinical responses, patients ultimately relapse as a reservoir of drug‐tolerant cells persist, which ultimately leads t...

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Veröffentlicht in:Int J Cancer
Hauptverfasser: Giron, Philippe, Eggermont, Carolien, Noeparast, Amir, Vandenplas, Hugo, Teugels, Erik, Forsyth, Ramses, De Wever, Olivier, Aza‐Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2021
Schlagworte:
Molecular Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048518/
https://ncbi.nlm.nih.gov/pubmed/33210294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33404
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