Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer

In non‐small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase inhibitors. Despite impressive clinical responses, patients ultimately relapse as a reservoir of drug‐tolerant cells persist, which ultimately leads t...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Giron, Philippe, Eggermont, Carolien, Noeparast, Amir, Vandenplas, Hugo, Teugels, Erik, Forsyth, Ramses, De Wever, Olivier, Aza‐Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2021
Assuntos:
Molecular Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048518/
https://ncbi.nlm.nih.gov/pubmed/33210294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33404
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