A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins

HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause Charcot‐Marie‐Tooth (CMT) disease, the most common inherited disorder of the peripheral nervous system. A particularly severe form of CMT disease i...

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Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2021
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047445/
https://ncbi.nlm.nih.gov/pubmed/33644875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103811
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