A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins

HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause Charcot‐Marie‐Tooth (CMT) disease, the most common inherited disorder of the peripheral nervous system. A particularly severe form of CMT disease i...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047445/
https://ncbi.nlm.nih.gov/pubmed/33644875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103811
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