Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype

The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prevent early T cell exhaustion during expansion. Acti...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Nakamura, Kayoko, Yagyu, Shigeki, Hirota, Shogo, Tomida, Akimasa, Kondo, Makoto, Shigeura, Tomokuni, Hasegawa, Aiko, Tanaka, Miyuki, Nakazawa, Yozo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047430/
https://ncbi.nlm.nih.gov/pubmed/33898630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.011
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