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Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype
The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prevent early T cell exhaustion during expansion. Acti...
Enregistré dans:
| Publié dans: | Mol Ther Methods Clin Dev |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Gene & Cell Therapy
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8047430/ https://ncbi.nlm.nih.gov/pubmed/33898630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.011 |
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