Pleiotropic consequences of metabolic stress on the major histocompatibility complex class II molecule antigen processing and presentation machinery

Hyperglycemia and hyperlipidemia are often observed in patients with Type II Diabetes (T2D) and related mouse models. One dysmetabolic biochemical consequence is the non-enzymatic reaction between sugars, lipids and proteins, favoring protein glycation, glycoxidation and lipoxidation. Here, we ident...

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Publicado no:Immunity
Main Authors: Clement, Cristina C., Nanaware, Padma P., Yamazaki, Takahiro, Negroni, Maria Pia, Ramesh, Karthik, Morozova, Kateryna, Thangaswamy, Sangeetha, Graves, Austin, Kim, Hei Jung, Li, Tsai Wanxia, Vigano’, Marco, Soni, Rajesh K., Gadina, Massimo, Tse, Harley Y., Galluzzi, Lorenzo, Roche, Paul A., Denzin, Lisa K., Stern, Lawrence J., Santambrogio, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046741/
https://ncbi.nlm.nih.gov/pubmed/33725478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.02.019
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