Follicular lymphoma-associated BTK mutations are inactivating resulting in augmented AKT activation

PURPOSE: Based on the recent discovery of mutations in Bruton’s tyrosine kinase (BTK) in Follicular Lymphoma (FL), we studied their functional properties. EXPERIMENTAL DESIGN: We identified novel somatic BTK mutations in 7% of a combined total of 139 FL and 11 transformed FL cases, none of which had...

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Pubblicato in:Clin Cancer Res
Autori principali: Hu, Nan, Wang, Fangyang, Sun, Tianyu, Xu, Zhengfan, Zhang, Jing, Bernard, Denzil, Xu, Shilin, Wang, Shaomeng, Kaminski, Mark, Devata, Suma, Phillips, Tycel, Malek, Sami N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046715/
https://ncbi.nlm.nih.gov/pubmed/33419778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3741
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