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Evaluation of the antiproliferative effects of the HASPIN inhibitor CHR-6494 in breast cancer cell lines
HASPIN is a serine/threonine kinase that regulates mitosis by phosphorylating histone H3 at threonine 3. The expression levels of HASPIN in various cancers are associated with tumor malignancy and poor survival, suggesting that HASPIN inhibition may suppress cancer growth. As HASPIN mRNA levels are...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8046223/ https://ncbi.nlm.nih.gov/pubmed/33852630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0249912 |
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