Cross-reactive immunogenicity of group A streptococcal vaccines designed using a recurrent neural network to identify conserved M protein linear epitopes

The M protein of group A streptococci (Strep A) is a major virulence determinant and protective antigen. The N-terminal sequence of the protein defines the more than 200 M types of Strep A and also contains epitopes that elicit opsonic antibodies, some of which cross-react with heterologous M types....

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Dettagli Bibliografici
Pubblicato in:Vaccine
Autori principali: Spencer, Jay A., Penfound, Tom, Salehi, Sanaz, Aranha, Michelle P., Wade, Lauren E., Agarwal, Rupesh, Smith, Jeremy C., Dale, James B., Baudry, Jerome
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045747/
https://ncbi.nlm.nih.gov/pubmed/33642159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2021.01.075
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