Structure-Based Design of Broadly Protective Group A Streptococcal M Protein-Based Vaccines

BACKGROUND: A major obstacle to the development of broadly protective M protein-based group A streptococcal (GAS) vaccines is the variability within the N-terminal epitopes that evoke potent bactericidal antibodies. The concept of M type-specific protective immune responses has recently been challen...

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Pubblicato in:Vaccine
Autori principali: Dale, James B., Smeesters, Pierre R., Courtney, Harry S., Penfound, Thomas A., Hohn, Claudia M., Smith, Jeremy C., Baudry, Jerome Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143202/
https://ncbi.nlm.nih.gov/pubmed/27890396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.11.065
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