Structure-based group A streptococcal vaccine design: Helical wheel homology predicts antibody cross-reactivity among streptococcal M protein–derived peptides

Group A streptococcus (Strep A) surface M protein, an α-helical coiled-coil dimer, is a vaccine target and a major determinant of streptococcal virulence. The sequence-variable N-terminal region of the M protein defines the M type and also contains epitopes that promote opsonophagocytic killing of s...

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Udgivet i:J Biol Chem
Main Authors: Aranha, Michelle P., Penfound, Thomas A., Spencer, Jay A., Agarwal, Rupesh, Baudry, Jerome, Dale, James B., Smith, Jeremy C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086045/
https://ncbi.nlm.nih.gov/pubmed/32029479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011258
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