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Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases

Intracellular proteolysis by the ubiquitin–proteasome system regulates numerous processes and contributes to protein quality control (PQC) in all eukaryotes. Covalent attachment of ubiquitin to other proteins is specified by the many ubiquitin ligases (E3s) expressed in cells. Here we determine the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genetics
Main Authors: Hickey, Christopher M, Breckel, Carolyn, Zhang, Mengwen, Theune, William C, Hochstrasser, Mark
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045714/
https://ncbi.nlm.nih.gov/pubmed/33683364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyaa031
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