A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons

A subset of proteins targeted by the N-end rule pathway bear degradation signals called N-degrons, whose determinants include destabilizing N-terminal residues. Our previous work identified mouse UBR1 and UBR2 as E3 ubiquitin ligases that recognize N-degrons. Such E3s are called N-recognins. We repo...

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Detalhes bibliográficos
Main Authors: Tasaki, Takafumi, Mulder, Lubbertus C. F., Iwamatsu, Akihiro, Lee, Min Jae, Davydov, Ilia V., Varshavsky, Alexander, Muesing, Mark, Kwon, Yong Tae
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190250/
https://ncbi.nlm.nih.gov/pubmed/16055722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7120-7136.2005
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