Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors

The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects of the complex challenges to bring this technology...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Evans, Amanda L., Dalby, Amanda, Foster, Holly R., Howard, Daniel, Waller, Amie K., Taimoor, Momal, Lawrence, Moyra, Mookerjee, Souradip, Lehmann, Marcus, Burton, Annie, Valdez, Jorge, Thon, Jonathan, Italiano, Joseph, Moreau, Thomas, Ghevaert, Cedric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045491/
https://ncbi.nlm.nih.gov/pubmed/33843988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003236
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