Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors

The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects of the complex challenges to bring this technology...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Evans, Amanda L., Dalby, Amanda, Foster, Holly R., Howard, Daniel, Waller, Amie K., Taimoor, Momal, Lawrence, Moyra, Mookerjee, Souradip, Lehmann, Marcus, Burton, Annie, Valdez, Jorge, Thon, Jonathan, Italiano, Joseph, Moreau, Thomas, Ghevaert, Cedric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045491/
https://ncbi.nlm.nih.gov/pubmed/33843988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003236
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