Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors

The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects of the complex challenges to bring this technology...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Evans, Amanda L., Dalby, Amanda, Foster, Holly R., Howard, Daniel, Waller, Amie K., Taimoor, Momal, Lawrence, Moyra, Mookerjee, Souradip, Lehmann, Marcus, Burton, Annie, Valdez, Jorge, Thon, Jonathan, Italiano, Joseph, Moreau, Thomas, Ghevaert, Cedric
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045491/
https://ncbi.nlm.nih.gov/pubmed/33843988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003236
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