Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors

The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects of the complex challenges to bring this technology...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Evans, Amanda L., Dalby, Amanda, Foster, Holly R., Howard, Daniel, Waller, Amie K., Taimoor, Momal, Lawrence, Moyra, Mookerjee, Souradip, Lehmann, Marcus, Burton, Annie, Valdez, Jorge, Thon, Jonathan, Italiano, Joseph, Moreau, Thomas, Ghevaert, Cedric
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045491/
https://ncbi.nlm.nih.gov/pubmed/33843988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003236
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