Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation

Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Liggett, L. Alexander, Galbraith, Matthew D., Smith, Keith P., Sullivan, Kelly D., Granrath, Ross E., Enriquez-Estrada, Belinda, Kinning, Kohl T., Shaw, Jessica R., Rachubinski, Angela L., Espinosa, Joaquin M., DeGregori, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Stimulus Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045490/
https://ncbi.nlm.nih.gov/pubmed/33787858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003858
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