IL-15 stimulation with TIGIT blockade reverses CD155-mediated NK cell dysfunction in melanoma

PURPOSE: Natural Killer (NK) cells play a critical role in tumor immunosurveillance. Multiple activating and inhibitory receptors regulate NK cell-mediated tumor control. The inhibitory receptor TIGIT and its counter-receptor CD226 exert opposite effects on NK cell-mediated tumor reactivity. EXPERIM...

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Udgivet i:Clin Cancer Res
Main Authors: Chauvin, Joe-Marc, Ka, Mignane, Pagliano, Ornella, Menna, Carmine, Ding, Quanquan, DeBlasio, Richelle, Sanders, Cindy, Hou, Jiajie, Li, Xian-Yang, Ferrone, Soldano, Davar, Diwakar, Kirkwood, John M., Johnston, Robert, Korman, Alan J., Smyth, Mark J., Zarour, Hassane M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045409/
https://ncbi.nlm.nih.gov/pubmed/32591463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0575
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