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IL-15 stimulation with TIGIT blockade reverses CD155-mediated NK cell dysfunction in melanoma
PURPOSE: Natural Killer (NK) cells play a critical role in tumor immunosurveillance. Multiple activating and inhibitory receptors regulate NK cell-mediated tumor control. The inhibitory receptor TIGIT and its counter-receptor CD226 exert opposite effects on NK cell-mediated tumor reactivity. EXPERIM...
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| 出版年: | Clin Cancer Res |
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| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8045409/ https://ncbi.nlm.nih.gov/pubmed/32591463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0575 |
| タグ: |
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