RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA studies, we investigated RRM2B alterations in cancer. We found that RRM2B is...

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Vydáno v:Front Genet
Hlavní autoři: Iqbal, Waleed, Demidova, Elena V., Serrao, Samantha, ValizadehAslani, Taha, Rosen, Gail, Arora, Sanjeevani
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045241/
https://ncbi.nlm.nih.gov/pubmed/33868369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.628758
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