RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy

RRM2B plays a crucial role in DNA replication, repair and oxidative stress. While germline RRM2B mutations have been implicated in mitochondrial disorders, its relevance to cancer has not been established. Here, using TCGA studies, we investigated RRM2B alterations in cancer. We found that RRM2B is...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Iqbal, Waleed, Demidova, Elena V., Serrao, Samantha, ValizadehAslani, Taha, Rosen, Gail, Arora, Sanjeevani
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045241/
https://ncbi.nlm.nih.gov/pubmed/33868369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.628758
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