Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma

Drug resistance and disease recurrence are important contributors for the poor prognosis of glioblastoma multiforme (GBM). Temozolomide (TMZ), the standard chemotherapy for GBM treatment, can methylate DNA and cause the formation of double-strand breaks (DSBs). X-ray repair cross complementing 5 (XR...

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Bibliografiske detaljer
Udgivet i:Oncol Lett
Main Authors: Lee, I-Neng, Yang, Jen-Tsung, Huang, Cheng, Huang, Hsiu-Chen, Wu, Yu-Ping, Chen, Jui-Chieh
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2021
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045174/
https://ncbi.nlm.nih.gov/pubmed/33868481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12704
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