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Effect of prior therapy on tumor mutational burden in NSCLC

BACKGROUND: Higher tumor mutation burden (TMB) in advanced non-small cell lung cancer (NSCLC) is associated with superior outcomes with checkpoint inhibitor therapy. Tissue samples subject to TMB analysis may be acquired after DNA-damaging therapies such as chemotherapy or radiation. The impact of t...

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Publicat a:Transl Lung Cancer Res
Autors principals: Jonna, Sushma, Vanderwalde, Ari, Nieva, Jorge, Poorman, Kelsey Anne, Saul, Michelle, von Buttlar, Xinyu, Hu, John Y., Liu, Stephen V.
Format: Artigo
Idioma:Inglês
Publicat: AME Publishing Company 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044473/
https://ncbi.nlm.nih.gov/pubmed/33889505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr-20-1076
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