Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart

AIMS: Adenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We hypothesised that increased AK1 activity would have negligible effects at rest, but protect against ischaemia/reperfusion (I/R) injury. METHO...

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Pubblicato in:Front Physiol
Autori principali: Zervou, Sevasti, McAndrew, Debra J., Whittington, Hannah J., Lake, Hannah A., Park, Kyung Chan, Cha, Kuan Minn, Ostrowski, Philip J., Eykyn, Thomas R., Schneider, Jürgen E., Neubauer, Stefan, Lygate, Craig A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044416/
https://ncbi.nlm.nih.gov/pubmed/33867998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.623969
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