Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and is down-regulated in chronic heart failure, which may contribute to disease progression. We hypothesised that cardiomyocyte-specific overexpression of Mt-CK would mitigate against these changes and thereby p...

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Publicat a:Basic Res Cardiol
Autors principals: Cao, Fang, Maguire, Mahon L., McAndrew, Debra J., Lake, Hannah A., Neubauer, Stefan, Zervou, Sevasti, Schneider, Jürgen E., Lygate, Craig A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2020
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Original Contribution
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954138/
https://ncbi.nlm.nih.gov/pubmed/31925563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-0777-3
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