AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even so, there are few AAV capsids that transduce both inner and outer hair cells—the cells that express most deafness genes—and fewe...

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Bibliografiska uppgifter
I publikationen:Mol Ther Methods Clin Dev
Huvudupphovsmän: Ivanchenko, Maryna V., Hanlon, Killian S., Hathaway, Daniel M., Klein, Alex J., Peters, Cole W., Li, Yaqiao, Tamvakologos, Panos I., Nammour, Josette, Maguire, Casey A., Corey, David P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2021
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044388/
https://ncbi.nlm.nih.gov/pubmed/33869656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.019
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